Correlation between elevated expression of LBX2 gene and prognosis in colorectal cancer
10.3969/j.issn.1009-9905.2024.08.004
- VernacularTitle:LBX2基因高表达与结直肠癌预后的相关性研究
- Author:
Lin-Hui QIAN
1
;
Hai-Jiao WANG
;
Xiao LI
;
Jian-Gang LIU
Author Information
1. 山东省泰安市肥城市人民医院肛肠外科(山东 泰安 271600)
- Keywords:
Colorectal neoplasms;
LBX2;
Prognosis;
Biomarker
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(8):607-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression level of LBX2 in colorectal cancer and re-veal the potential role of LBX2 in colorectal cancer progression.Methods:The present study em-ployed utilized data mining techniques on the Cancer Genome Atlas database to compare the ex-pression level of LBX2 in matched colorectal cancer and normal tissues.Additionally,an investiga-tion was conducted to explore the relationship between clinicopathological features and LBX2 ex-pression.Furthermore,a receiver operating characteristic curve was generated to assess the diag-nostic value of LBX2.Results:A statistically significant divergence in patient prognosis was ob-served between those with high and low expression levels.Elevated levels of LBX2 have been identified as a significant independent prognostic indicator for colorectal cancer,correlating with decreased overall survival and disease-specific survival.Conclusion:Patients with high expres-sion of LBX2 exhibit a considerably poor prognosis,thus highlighting its potential as a valuable prognostic biomarker for individuals diagnosed with colorectal cancer.
