Highly oxidized sesquiterpenoids from Parasenecio rubescens and assessment of their cytotoxicity
10.1016/S1875-5364(24)60607-2
- Author:
An JIN
1
;
Fangfang DUAN
;
Hanli RUAN
Author Information
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,China
- Keywords:
Parasenecio rubescens;
Asteraceae;
Bisabolane-type sesquiterpenoids;
Oplopane-type sesquiterpenoid;
Cytotoxic activity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(11):1020-1029
- CountryChina
- Language:Chinese
-
Abstract:
A phytochemical investigation of the whole plant of Parasenecio rubescens(S.Moore)Y.L.Chen yielded 14 previ-ously undescribed,highly oxidized bisabolane-type sesquiterpenoids,named pararunines L-Y,along with one known oplopane-type sesquiterpenoid.The structural elucidation of these compounds was accomplished through comprehensive spectroscopic analysis,in-cluding nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS)techniques.Motivated by traditional uses and previous studies on this genus,all isolated compounds were subjected to in vitro cytotoxicity assays against four human cancer cell lines(MCF-7,Hela,HCT116,and HT-29).Considering that the reported chemical constituents of nu-merous other species within this genus primarily consist of eremophilane-type sesquiterpenoids,our findings not only expand the struc-tural diversity of bisabolane-type sesquiterpenoids but also contribute valuable scientific evidence to the chemotaxonomy of this genus.
