Correlation between inflammatory markers and fibrosis of metabolic dysfunction-associated fatty liver disease in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.10.003
- VernacularTitle:2型糖尿病合并代谢相关脂肪性肝病肝纤维化相关炎症指标的研究
- Author:
Ying ZHANG
1
;
Rui HUANG
;
Xue ZHANG
;
Kuanlu FAN
Author Information
1. 221000 徐州医科大学第二附属医院内分泌科
- Keywords:
Inflammatory markers;
Diabetes mellitus,type 2;
Metabolic dysfunction-associated fatty liver disease;
Liver fibrosis
- From:
Chinese Journal of Diabetes
2024;32(10):731-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between inflammatory markers and fibrosis of metabolic dysfunction-associated fatty liver disease(MAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 769 hospitalized patients with T2DM were enrolled in this study from the Department of Endocrinology,The Second Affiliated Hospital of Xuzhou Medical University from January 2020 to December 2023.They were divided into T2DM group(n=389)and MAFLD group(n=380)according to whether they were combined with MAFLD.According to the FIB-4 score,the MAFLD group was further divided into non-hepatic fibrosis subgroup(FIB-4＜1.3,n=267),suspected hepatic fibrosis subgroup(1.3≤FIB-4≤2.67,n=99)and advanced hepatic fibrosis subgroup(FIB-4＞2.67,n=14).The general data and biochemical indicators of each group were compared,Logistic regression analysis of influencing factors for liver fibrosis in T2DM patients with MAFLD.The diagnostic value of NLR,SIRI,PLR and PHR in predicting T2DM complicated with MAFLD liver fibrosis was evaluated by ROC curve analysis.Results BMI,lymphocytes(LY),red blood cells(RBC),hemoglobin(Hb),FPG,TG,TC,LDL-C,alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),γ-glutamyl transpeptidase(GGT),and serum uric acid(SUA)were higher,while age,duration of DM,mean platelet volume and high-density lipoprotein cholesterol(HDL-C)were lower in MAFLD group than in T2DM group(P＜0.05).Compared with the non-hepatic fibrosis subgroup,the age,duration of DM,mean platelet volume AST and NLR were increased,while LY,PLR and PHR were decreased in the suspected hepatic fibrosis subgroup(P＜0.05).The age,AST and NLR were higher,while LY,RBC,LDL-C,PLR and PHR were lowerin the advanced hepatic fibrosis subgroup than in non-hepatic fibrosis subgroup(P＜0.05).Compared with the suspected hepatic fibrosis subgroup,FPG,HbA1c and SIRI were increased(P＜0.05),however,Hb,PLT and ALB were decreased in the advanced hepatic fibrosis subgroup(P＜0.05).Logistic regression analysis showed that NLR,SIRI,PLR and PHR were the influencing factors for liver fibrosis in T2DM combined with MAFLD.Area under ROC curve for NLR,SIRI,PLR and PHR in predicting liver fibrosis in T2DM combined with MAFLD were 0.712,0.757,0.703,0.806,respectively.The sensitivities were 0.929,0.500,0.857,0.929,and the specificities were 0.388,0.902,0.497,0.593 respectively.The optimal cut-off values were 1.573、1.465、110.819、185.379.Conclusions NLR,SIRI,PLR and PHR are the influencing factors for liver fibrosis in patients with T2DM complicated with MAFLD,which are helpful for their diagnosis.
