Relationship between Vitamin D receptor gene polymorphism and genetic susceptibility in gestational diabetes mellitus
10.3969/j.issn.1006-6187.2024.06.006
- VernacularTitle:维生素D受体基因多态性与妊娠期糖尿病遗传易感性相关性的研究
- Author:
Shaohua ZHANG
1
;
Mengbin LIU
Author Information
1. 430000 武汉亚心总医院妇产科
- Keywords:
Gestational diabetes mellitus;
Genetic susceptibility;
Vitamin D receptor;
Gene polymorphism
- From:
Chinese Journal of Diabetes
2024;32(6):427-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between vitamin D receptor(VDR)gene polymorphisms and genetic susceptibility in gestational diabetes mellitus(GDM).Methods A total of 240 patients with GDM who were hospitalized in the Obstetrics and Gynecology Department of Wuhan Yaxin General Hospital were enrolled in this study from January 2019 to January 2022(GDM group),and another 240 healthy pregnant women matched were selected as normal control(NC)group during the same period.The general information,FPG,HbA1c,2 hour postprandial blood glucose(2 hPG),insulin resistance index(HOMA-IR),serum 25 hydroxyvitamin D[25(OH)D]level,and VDR gene polymorphisms were compared between the two groups.The correlation between HOMA-IR and 25(OH)D levels was evaluated by Pearson analysis.The influencing factors for GDM genetic susceptibility were analyzed by logistic regression model.The pregnancy outcomes of GDM patients were analyzed by follow-up to the end of pregnancy.Results The prevalence of DM family history,FPG,2 hPG,HbA1c and HOMA-IR were higher(P<0.05),whilethe serum 25(OH)D was lower in GDM group than in NC group(P<0.05).There was significant difference in the distribution of genotype and allele frequency of FokI locus of VDR gene between the two groups(P<0.05).Pearson correlation analysis showed that serum 25(OH)D was negatively correlated with FPG,2 hPG,HbA1c and HOMA-IR(P<0.05).Logistic regression analysis showed that DM family history,VDR gene FokI genotype GA and AA were the influencing factors for GDM genetic susceptibility.The incidence of adverse pregnancy outcome was higher in patients with FokI AA genotype than in patients with GA and GG genotypes(P<0.05).The incidence of adverse pregnancy outcome was higher in patients with GA genotype than in patients with GG genotype(P<0.05).Conclusions The VDR gene FokI locus gene polymorphism is associated with the genetic susceptibility to GDM,and its GA and AA genotypes both increase the risk of GDM susceptibility and the incidence of adverse pregnancy outcomes.
