Research progress on the role of Rheb1 in diabetes mellitus and its complications
10.3969/j.issn.1006-6187.2024.05.015
- VernacularTitle:Rheb1在糖尿病及其并发症中作用的研究进展
- Author:
Xiao HU
1
;
Qingmiao LU
;
Yibing LU
Author Information
1. 210011 南京医科大学第二附属医院内分泌科
- Keywords:
Rheb1;
Diabetes mellitus;
mTORC1;
Mitochondria
- From:
Chinese Journal of Diabetes
2024;32(5):395-398
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus(DM)is a chronic metabolic disease characterized by sustained elevation of blood glucosedue toin sulin resistance and islet β cell damage.Rheb1 regulates cell growth and metabolism,promotes islet β cell growth,proliferation and insulin secretion through the mTORC1 pathway,affects the function of vascular endothelial cells,macrophages and glomerular podocytes,and participates in the occurrence and development of atherosclerosis and diabetic kidney disease.This article reviews the research progress on the role of Rheb1 in DM and its complications.
