Research Advances in Strategies to Enhance the Therapeutic Effects of Mesenchymal Stem Cells on Graft-Versus-Host Disease Post Hematopoietic Stem Cell Transplantation——Review

VernacularTitle:间充质干细胞治疗造血干细胞移植后移植物抗宿主病的增效策略研究进展
Author: Run-Xiang XU ¹ ; Pei-Lin LI ; Heng ZHU ; Li DING
Author Information

1. 空军军医大学研究生院,陕西西安 710032;空军特色医学中心血液科,北京 100142;北京辐射医学研究所,北京 100850
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease; mesenchymal stem cells; strategies for enhancing the efficacy
From: Journal of Experimental Hematology 2024;32(6):1923-1927
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells (MSC) possess unique immunomodulatory properties and have enormous potential in the treatment of graft-versus-host disease (GVHD). However,the low implantation and survival rates of MSC in vivo,coupled with their weak immunosuppressive functions,have resulted in unstable clinical efficacy in the treatment of GVHD. Preconditioning of MSC with hypoxia,active molecules and gene modification can enhance the function of MSC and improve the implantation rate,survival rate and therapeutic effect of MSC. This review summarized the strategies for enhancing the efficacy of MSC in the treatment of hematopoietic stem cell transplantation complicated with GVHD in recent years,aiming to provide new strategies for optimizing the application of MSC in the prevention and treatment of GVHD.