The Role of Matrix Metalloproteinase-13 in Multiple Myeloma
10.19746/j.cnki.issn1009-2137.2024.06.022
- VernacularTitle:基质金属蛋白酶-13在多发性骨髓瘤中的作用研究
- Author:
Hai-Ying JIA
1
;
Shu-Li GUO
;
Liang YU
;
Guo-Hong HUANG
;
Chang-Min WANG
Author Information
1. 新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐 830001
- Keywords:
matrix metalloproteinase-13;
multiple myeloma;
myeloma bone disease;
stage;
treatment efficacy
- From:
Journal of Experimental Hematology
2024;32(6):1776-1780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of matrix metalloproteinase-13 (MMP-13) in the development,diagnosis and prognosis of multiple myeloma (MM). Methods:Blood samples of 57 MM patients and 45 normal controls were collected,and real-time PCR was performed to detect the MMP-13 mRNA expression level in the study subjects,and the difference of MMP-13 mRNA level between MM patients and normal controls was compared. The correlations of MMP-13 with MM bone disease and its severity,ISS stage,DS stage,and treatment efficacy were analyzed. Results:The MMP-13 mRNA in patients with MM was significantly higher than that in normal controls (P<0.05). The MMP-13 mRNA in MM patients with bone disease was significantly higher than that in patients without bone disease,and the more severe the bone disease,the more obvious the increase in MMP-13 mRNA (P<0.05). The MMP-13 gene expression level was also significantly different between ISS and DS stage Ⅰ and stage Ⅲ patients (P<0.05),and the MMP-13 mRNA level was significantly decreased after treatment (P<0.05). Conclusion:The MMP-13 mRNA expression level is related to the occurrence and development of MM,and it has certain guiding significance in disease diagnosis and prognosis evaluation.
