Diagnosis and Risk Stratification of Acute Myeloid Leukemia,Myelodysplasia-Related
10.19746/j.cnki.issn1009-2137.2024.05.010
- VernacularTitle:骨髓增生异常相关急性髓系白血病的诊断及风险分层
- Author:
Hui YANG
1
;
Rui GUO
;
Yu SHI
;
Chun QIAO
;
Yan WANG
;
Yu-Jie WU
;
Hai-Rong QIU
Author Information
1. 南京医科大学第一附属医院,江苏省人民医院血液科,江苏南京 210029
- Keywords:
acute myeloid leukemia,myelodysplasia-related;
molecular genetics;
diagnosis;
risk stratification
- From:
Journal of Experimental Hematology
2024;32(5):1372-1376
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical and genetic characteristics of acute myeloid leukemia,myelodysplasia-related(AML-MR)patients and evaluate their prognostic risk stratification,to guide clinical treatment decisions and improve understanding of the biological characteristics and disease progression.Methods:The study analyzed cellular and molecular genetic information of 307 AML-MR patients,diagnosed based on clinical history,bone marrow morphology,cytogenetics,and molecular genetic abnormalities.The risk stratification followed the 2022 ELN guidelines.Results:57 cases(18.6％)met the AML-MR diagnostic criteria based on morphology and clinical history,110 cases(37.2％)met the AML-MR diagnostic criteria based on cytogenetic results,and 210 cases(74.5％)met the AML-MR diagnostic criteria based on molecular testing results.Among different type of mutations,ASXL1 mutation was the most frequent,followed by SRSF2 and BCOR mutations.Except for 2 cases with incomplete data that could not be classified.263(86.2％)of the 305 patients were classified as poor prognosis,20(6.6％)were classified as good prognosis group,and 22(7.2％)were classified as intermediate prognosis group.Conclusion:Molecular genetic information plays a crucial role in diagnosing AML-MR,highlighting the importance of genetics in diagnosis and prognosis.Most AML-MR patients fall into poor prognosis categories,necessitating early intensive and targeted therapy for better survival outcomes.
