Research Progress on the Influence of Blood Tumor Microen-vironment on the Efficacy and the Adverse Reactions of CAR-T Cell Immunotherapy——Review
10.19746/j.cnki.issn1009-2137.2024.04.048
- VernacularTitle:血液肿瘤微环境对CAR-T免疫疗法疗效及其不良反应的影响的研究进展
- Author:
Cai-Feng LIAO
1
;
Hu-Rong LAI
;
Jian LI
Author Information
1. 南昌大学第二附属医院血液科、血液重点实验室;南昌大学医学部,江西南昌 330006
- Keywords:
tumor microenvironment;
chimeric antigen receptor T cells;
immunotherapy;
hematologic malignancies
- From:
Journal of Experimental Hematology
2024;32(4):1290-1294
- CountryChina
- Language:Chinese
-
Abstract:
The application of chimeric antigen receptor T cell(CAR-T)immunotherapy has ushered in a new era in cancer therapy,especially in the treatment of many kinds of refractory malignant tumors.The curative effect is significant for refractory/recurrent hematologic malignancies,such as acute leukemia,lymphoma,and multiple myeloma(MM).Tumor microenvironment(TME)is closely related to the efficacy and adverse reactions of CAR-T therapy.TME not only affects the activity of CAR-T cells,reduces their anti-tumor ability,but also directly involved in the occurrence and development of CAR-T cell therapy-related adverse reactions,such as cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).Therefore,a deeper understanding of the role of blood TME in the process of CAR-T immunotherapy and the occurrence and development of adverse reactions is helpful for the application of CAR-T therapy in hematological malignancies.In this review,the influence of blood TME on the efficacy and adverse reactions of CAR-T immunotherapy was briefly summarized,aiming to provide evidence-based support for the clinical optimization of therapeutic regimen of refractory/recurrent hematologic malignancies.
