Research Progress on the Mechanism of PI3K/AKT/mTOR Signa-ling Pathway in Multiple Myeloma

VernacularTitle:PI3K/AKT/mTOR信号通路在多发性骨髓瘤中作用机制的研究进展
Author: Qing-Qing LIU ¹ ; Yi-Qiang LI ; Wei-Min CHENG
Author Information

1. 广西中医药大学研究生学院,广西南宁 530001
Keywords: PI3K/AKT/mTOR; multiple myeloma; mechanism of action
From: Journal of Experimental Hematology 2024;32(1):292-296
CountryChina
Language:Chinese
Abstract: PI3K/AKT/mTOR signaling pathway is of great significance in the development and prognosis of tumors,and is closely related to the pathogenesis of multiple myeloma(MM).PI3K/AKT/mTOR signaling pathway can participate in the regulation of MM through multi-channel and multi-target,such as regulating the tumor microenvironment of MM cells survival,affecting tumor development and migration,regulating the proliferation,apoptosis and autophagy of MM cells.It have shown that after the PI3K/AKT/mTOR signaling pathway is inhibited,the apoptosis and autophagy of MM cells are activated,which promote the death of MM cells and inhibit the metastasis and recurrence of MM cells.Therefore,in-depth study of the mechanism of PI3K/AKT/mTOR signaling pathway in MM is helpful to elucidate the pathogenesis and prognosis of MM.