Research Progress of Circular RNA in Acute Myeloid Leukemia
10.19746/j.cnki.issn1009-2137.2024.01.045
- VernacularTitle:环状RNA在急性髓系白血病中的研究进展
- Author:
Dong-Hua LI
1
;
Jin-Cai YANG
;
Li ZHAO
Author Information
1. 兰州大学第一临床医学院,甘肃兰州 730000
- Keywords:
acute myeloid leukemia;
circular RNA;
drug resistance;
prognosis
- From:
Journal of Experimental Hematology
2024;32(1):282-286
- CountryChina
- Language:Chinese
-
Abstract:
Acute myeloid leukemia(AML)is a malignant tumor of the blood system that is highly heterogeneous in terms of pathogenesis,genetic background and prognostic outcome,with an extremely high fatality rate and recurrence rate.Therefore,exploring new treatment methods and diagnostic strategies is one of the ways to improve the survival rate of patients with acute myeloid leukemia.Circular RNA(circRNA)is a special kind of non-coding RNA,which plays an important role in gene transcription,translation and epigenetic modification,and participates in the disease progression and prognosis of multiple solid tumors.At present,it has found that the abnormal expression of circRNA is closely related to the occurrence,development,drug resistance and prognosis of acute myeloid leukemia.Clinically,it can be used as a new biomarker and potential therapeutic target for AML.This article briefly reviews the research progress of circRNA in acute myeloid leukemia,aiming to provide new strategies for optimizing the diagnosis,treatment and prognosis of leukemia.
