Roles of interleukin-17 in major bacterial zoonoses and its mechanisms

VernacularTitle:白细胞介素-17在主要细菌性人兽共患病中的作用及其机制
Author: Aijun LIU ¹ ; Xiaobing HUANG ; Caiqin ZHOU ; Chuanliang ZHANG
Author Information

1. 浙江省动物疫病预防控制中心,浙江杭州 311199
Keywords: IL-17; bacteria; zoonoses; immunity
From: Chinese Journal of Veterinary Science 2024;44(6):1316-1324
CountryChina
Language:Chinese
Abstract: Interleukin-17(IL-17)is an important pro-inflammatory cytokine that bridges innate and adaptive immunity,promoting protective immunity against pathogens,but also driving inflamma-tory pathology during infection and autoimmunity.IL-17 has important protective roles in a variety of bacterial zoonoses,but also promotes the development of inflammatory diseases in various organ tissues and is associated with autoimmune diseases induced by bacterial infections.Recent studies have shown that IL-17-secreting CD4+tissue-resident T memory cells play a key role in sustaining adaptive immunity to bacterial infections,and vaccine design strategies targeting IL-17 responses exhibit apparent advantages in improving vaccine efficacy.In this regard,this paper reviews the bio-logical functions of IL-17 and its roles in major bacterial zoonoses and related mechanisms,with the aim of providing a reference for the development of safe and effective IL-17-based immunother-apies.