Research progress on the mechanism of miR-138-5p in osteoarthritis
10.3969/j.issn.1671-7856.2024.07.016
- VernacularTitle:miR-138-5p在骨关节炎中作用机制的研究进展
- Author:
Liangbin WU
1
;
Jian WENG
;
Aikang LI
;
Tiantian QI
;
Geng ZHANG
;
Hui ZENG
;
Fei YU
Author Information
1. 北京大学深圳医院骨关节科,广东深圳 518036;骨科生物材料国家地方联合工程研究中心,广东深圳 518036;深圳市骨科疾病与生物材料研究重点实验室,广东深圳 518036
- Keywords:
miR-138-5p;
osteoarthritis;
pathogenesis
- From:
Chinese Journal of Comparative Medicine
2024;34(7):142-149
- CountryChina
- Language:Chinese
-
Abstract:
MiR-138-5p is a microRNA that plays an important regulatory role in the pathogenesis of osteoarthritis.MiR-138-5p regulates various biological processes,including inflammation,cell apoptosis and proliferation,and matrix degradation in osteoarthritis,by modulating signaling pathways including nuclear factor-κB,Wnt/β-catenin,and phosphoinositide 3-kinase/AKT.This review summarizes the research progress regarding the mechanism of miR-138-5p in osteoarthritis.
