Progress in resource utilization and model animal research of Daurian ground squirrel

VernacularTitle:达乌尔黄鼠的资源利用及模式动物化研究进展
Author: Xin XING ¹ ; Youtao FU ; Xinyu LIU ; Ming YANG
Author Information

1. 沈阳师范大学生命科学学院,沈阳 110034
Keywords: Daurian ground squirrel; hibernation; experimental animal
From: Acta Laboratorium Animalis Scientia Sinica 2024;32(8):1052-1058
CountryChina
Language:Chinese
Abstract: The Daurian ground squirrel(Spermophilus dauricus)is the main animal model used for hibernation research in China.This species has many striking physiological adaptive characteristics,such as an adaptation to extreme hypothermia,a low metabolism,resistance to ischemia-reperfusion injury,disuse muscular atrophy,and unique mechanisms of body fat accumulation.These characteristics make the Daurian ground squirrel a unique and significant reference model with research value in clinical and space flight applications.The application of the Daurian ground squirrel as a model animal will help us to further explore the physiological mechanisms mentioned above.This review summarizes the biological characteristics and research values of Daurian ground squirrels in clinical and space flight applications.We also introduce the current progress made in the breeding and experimental animalization of Daurian ground squirrels for laboratory and field research,and advise on precautions that need to be considered during the experimental animalization of this species.