The Molecular Mechanism and Potential Clinical Value of Lysophosphatidic Acid in Macrophages
10.13865/j.cnki.cjbmb.2024.08.1201
- VernacularTitle:溶血磷脂酸在巨噬细胞中作用的分子机制及潜在临床价值
- Author:
Jia-Yi ZHAO
1
;
Xiao YANG
;
Xiao-Yun YANG
Author Information
1. 山东第二医科大学基础医学院生物化学与分子生物学系,山东 潍坊261053;山东第二医科大学基础医学院智能诊疗与分子疾病协同创新重点实验室,山东 潍坊261053
- Keywords:
lysophosphatidic acid (LPA);
macrophage;
tumor immunity;
cancer;
cell signal
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(11):1522-1530
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are an important class of immune cells that are mainly derived from myeloid pro-genitor cells in the bone marrow.They function in phagocytosis and antigen presentation,and participate in innate immune and inflammatory responses.Lysophosphatidic acid (LPA) is an active phospholipid signaling molecule that induces macrophage differentiation and polarization,regulates macrophage migra-tion and infiltration,and modulates the inflammatory response in which macrophages participate.In this paper,we review the molecular mechanisms underlying the role of LPA in macrophages in recent years by taking the role of LPA in macrophages as an entry point:LPA plays an important role in macrophage dif-ferentiation and polarization by inducing related regulatory factors and cytokines;LPA receptors mediaterelated signaling pathways to regulate macrophage migration and infiltration;and the ATX/LPA signaling axis and related cytokines are involved in macrophage inflammatory regulation.In addition,the regulatory role and potential clinical value of LPA in tumor-associated macrophages and macrophage inflammatory response diseases are reviewed.At present,the molecular mechanism of action of LPA in macrophages has not been fully elucidated.And an in-depth study of the receptor expression,biological roles,and regulatory mechanisms of LPA in macrophages will provide new strategies for the treatment of macro-phage-associated diseases and cancers.
