NLRP3 Inflammasome:An Important Target for Exercise in the Prevention and Treatment of Cardiovascular Diseases
10.13865/j.cnki.cjbmb.2024.08.1158
- VernacularTitle:核苷酸结合寡聚化结构域样受体蛋白3炎症小体:运动防治心血管疾病的重要靶点
- Author:
Jun CHEN
1
;
Shao-Hui JIA
;
Xin-Xuan XUE
Author Information
1. 武汉体育学院研究生院,武汉430079
- Keywords:
nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3);
inflammasome;
exercise;
cardiovascular diseases (CVD);
inflammation;
pyroptosis
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(11):1493-1503
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases (CVD) are the leading cause of death among residents in China and significantly impact patients' quality of life.The pathogenesis of CVD is complex,with chronic low-grade inflammation as a predominant feature.The nucleotide-binding oligomerization domain-like receptor pro-tein 3 (NLRP3) inflammasome is a key regulator of inflammatory responses and plays a crucial role in in-nate immune responses.Its abnormal activation leads to excessive inflammation and pyroptosis,which is closely associated with the development of atherosclerosis,myocardial infarction,diabetic cardiomyopa-thy,and other CVDs.Recent studies suggest that exercise,as a safe and effective non-pharmacological intervention,can mitigate cardiovascular inflammation and pyroptosis by inhibiting NLRP3 inflammasome activation,thereby playing a positive role in CVD prevention and treatment.However,the theories and mechanisms of exercise-mediated NLRP3 inflammasome intervention in CVD remain underexplored.Therefore,this review summarizes the relationship between the NLRP3 inflammasome and CVD,explores the effects of different types,intensities,and durations of exercise on NLRP3 inflammasome activation,and provides a comprehensive analysis of the signaling pathways involved in exercise interventions targe-ting the NLRP3 inflammasome for the prevention and treatment of CVD.The aim is to provide new in-sights and references for exercise-based prevention and management of CVD.
