The Impact of Amino Acid Metabolism Reprogramming on the Occurrence,Development,and Treatment of Hepatocellular Carcinoma
10.13865/j.cnki.cjbmb.2024.08.1088
- VernacularTitle:氨基酸代谢重编程对肝细胞癌发生发展及治疗的影响
- Author:
Qing ZHANG
1
;
Qing-Niao ZHOU
;
Wen-Zhen LIN
Author Information
1. 广西医科大学基础医学院生物化学与分子生物学教研室,南宁 530021;广西高校生物分子医学研究重点实验室,南宁 530021
- Keywords:
amino acid metabolism;
branched-chain amino acids(BCAA);
nonessential amino acids;
tumors;
hepatocellular carcinoma(HCC)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(10):1392-1399
- CountryChina
- Language:Chinese
-
Abstract:
In tumor cells,changes in specific amino acids can have a significant impact on the metabo-lism of cancer cells and alter the response of immune cells in the tumor microenvironment,affecting the occurrence,development,and therapeutic effects of tumors.This article first introduces the role of amino acids in tumors,exploring the metabolism of essential amino acids in tumors from the intake of exogenous amino acids,amino acid modification,and metabolism of branched chain amino acids,and clarify the role of nonessential amino acids in nonessential amino acid deficient tumors.Secondly,the impact of a-mino acid metabolism reprogramming on the occurrence and development of hepatocellular carcinoma was elucidated.Essential and nonessential amino acids play an indispensable role in hepatocellular carcinoma development.In liver cancer cells,the abnormally high content of essential amino acids promotes the oc-currence and development of liver cancer cells,but the increase of branched chain amino acid content has a dual effect.Nonessential amino acids often act as inhibitory factors in liver cancer cells,but arginine can combine with asparagine to form a positive feedback loop and promote the occurrence and develop-ment of liver cancer.Finally,the impact of amino acid metabolism reprogramming on the treatment of hepatocellular carcinoma was elucidated.Glutamate,serine,branched chain amino acids,S-adenosylme-thionine,glycine,arginine,etc.can serve as targets for liver cancer.Inhibiting the expression of glutar-ate dehydrogenase can improve the drug sensitivity of liver cancer patients to sorafenib.The reprogram-ming of amino acid metabolism in the tumor microenvironment of hepatocellular carcinoma promotes the malignant proliferation and immune escape of liver cancer cells.Studying the specific changes in amino acids is beneficial for developing personalized immunotherapy for patients.
