Mechanisms of Exercise to Improve Microglia-mediated Neuroinflammation in The Prevention of Parkinson's Disease
10.13865/j.cnki.cjbmb.2024.02.1388
- VernacularTitle:运动改善小胶质细胞介导的神经炎症在预防帕金森病的作用机制
- Author:
Nan LI
1
;
Ren-Qing ZHAO
;
Bin WANG
Author Information
1. 扬州大学体育学院,运动人体科学系,江苏扬州 225100
- Keywords:
exercise;
microglia;
neuroinflammation;
Parkinson's disease(PD);
oxidative stress
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(6):779-787
- CountryChina
- Language:Chinese
-
Abstract:
The loss of dopaminergic neurons in the substantia nigra compacta and the aggregation of α-synuclein are the hallmark symptoms of Parkinson's disease(PD),a prevalent neurodegenerative condi-tion.The pathological mechanisms of PD are very complex,and microglia activation-mediated neuroin-flammation has recently been found to be an important factor in dopaminergic neuronal loss in PD.Cur-rent pharmacological treatments can only alleviate the symptoms of dyskinesia but cannot slow down the pathological process.Exercise,as a non-pharmacological physical intervention,has been shown to be helpful in preventing and delaying the onset of neurodegenerative pathologies,and moderate exercise pro-duces some anti-inflammatory effects and reduces dopaminergic neuron loss.However,the regulatory mechanisms of exercise in ameliorating microglia-mediated neuroinflammation and preventing the patho-logical process of PD are not well understood.Some studies have found that exercise can ameliorate fac-tors associated with PD,such as abnormally aggregated α-synuclein,brain-derived neurotrophic factor levels,autophagy,and oxidative stress.Therefore,this paper describes the molecular mechanism of ex-ercise to improve microglia-mediated neuroinflammation in the prevention of Parkinson's disease from the above aspects and provides new therapeutic targets for the prevention and treatment of PD.
