Molecular Mechanisms and Antibacterial Strategies of Antibiotic Resistance
10.13865/j.cnki.cjbmb.2024.01.1365
- VernacularTitle:抗生素耐药性的分子机制及抑菌策略
- Author:
Hu-Liang LI
1
;
Lei ZHANG
Author Information
1. 天津大学生命科学学院14教学楼227室,天津 300072
- Keywords:
antibiotic resistance;
CRISPR-Cas system;
antisense therapy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(6):759-769
- CountryChina
- Language:Chinese
-
Abstract:
Antibiotic resistance is considered one of the most serious global threats to human health in the 21st century.The overuse of antibiotics has aggravated the development of bacterial resistance.Therefore,it is necessary to further study the mechanisms of bacterial resistance and explore new types of resistance and bacteriostatic strategies.This article provides an overview of the mechanisms of bacterial resistance and new antibacterial strategies for drug-resistant bacteria.It elaborates on the molecular mechanisms of three types of resistance:inherent resistance,acquired resistance and adaptive resistance.It also discusses new antibacterial strategies such as new antibacterial compound molecules,phage therapy,CRISPR-Cas system therapy and antisense therapy.This review aims to summarize the mechanisms of bacterial resistance and provide a reference for subsequent prevention and treatment of bacterial resistance.
