Adipose Tissue Microenvironments during Aging
10.13865/j.cnki.cjbmb.2024.02.1356
- VernacularTitle:衰老脂肪组织的微环境
- Author:
Yu-Jie ZHANG
1
;
Meng YANG
;
Xin-Guang LIU
Author Information
1. 广东省医学分子诊断重点实验室,广东医科大学衰老研究所,广东医科大学生物化学与分子生物学研究所,广东医科大学医学技术学院,广东东莞 523808
- Keywords:
adipose tissue;
aging;
microenvironment;
immunity;
metabolism
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(6):749-758
- CountryChina
- Language:Chinese
-
Abstract:
The adipose tissue serves as the largest energy storage and endocrine organ in the body.It plays a crucial role in regulating energy homeostasis and hormone secretion.However,with aging,the adipose tissue undergoes significant changes that can have detrimental effects on overall health.One of the key features of aging adipose tissue is the presence of senescent cells.These cells touch neighboring cells through the secretion of cytokines and the release of metabolites.This interaction can disrupt the normal function of adipose tissues and lead to systemic chronic inflammation or metabolic disorders.Cur-rently,the microenvironment of the aging adipose tissue has not been fully clarified.Therefore,here we review the changes in the microenvironment of aging adipose tissues,including various cell types in the adipose tissue,fibrosis caused by extracellular matrix accumulation,cytokine and metabolites.These al-terations can lead to systemic chronic low-grade inflammation,insulin resistance,and premature aging.Finally,several strategies expected to delay adipose tissue aging are introduced,including improving adi-pocyte thermogenesis,senolytics,diet and exercise.This review aims to provide ta heoretical reference for the treatment of ageing-related diseases.
