Genomic analysis of human quinolone resistant 1,4,5,12:i:-Salmonella in Jiangsu Province from 2014 to 2018
10.3969/j.issn.1002-2694.2024.00.120
- VernacularTitle:2014-2018年江苏省人源喹诺酮耐药1,4,[5],12:i:-沙门氏菌的基因组学初步分析
- Author:
Dong-Yu ZHENG
1
;
Kai MA
;
Yi-Jing ZHOU
;
Gao-Lin WU
;
Xiang HUO
;
Xin QIAO
Author Information
1. 江苏省疾病预防控制中心,南京 210009;国家卫生健康委员会肠道病原微生物重点实验室,南京 210009;江苏省新发突发重大传染病病原微生物重点实验室,南京 210009
- Keywords:
1,4,[5],12:i:-Salmonella;
quinolone resistance;
molecular epidemiology
- From:
Chinese Journal of Zoonoses
2024;40(8):739-744
- CountryChina
- Language:Chinese
-
Abstract:
The molecular epidemiological characteristics of 1,4,[5],12:i:-Salmonella in Jiangsu Province were analyzed through whole genome sequencing(WGS).The distribution characteristics of related genes were obtained on the basis of anno-tated drug-resistant genes and plasmid types in the whole genome.Analysis of the molecular epidemiological characteristics of strains with cgMLST revealed possible modes of transmission of quinolone resistance in 1,4,[5],12:i:-Salmonella.Eleven cat-egories of antibiotic resistance genes(ARGs)were annotated among the fluoroquinolone-resistant strains.The detection rate of aminoglycoside ARGs was highest(100％).Twelve quinolone-resistant strains(92.3％)carried the IncHI2/IncHI2A plasmid type.PMQR gene analysis of various strains indicated that the strains from the United States and Europe carried six types of PMQR genes,and the detection rate of qnrB19 was highest.The Jiangsu strains carried three PMQR gene types,and the de-tection rate of aac(6')-Ib-cr was highest(11.84％).Analysis of cgMLST loci from different countries/regions revealed three main epidemic clusters.Some isolates from Jiangsu province might have the same evolutionary origin as some isolates from Eu-rope and the United States,and national/regional differences were observed in the PMQR gene carriage level.
