Report of one case of Balamuthia mandrillaris encephalitis in Human
10.3969/j.issn.1002-2694.2024.00.092
- VernacularTitle:人体感染狒狒巴拉姆希阿米巴脑炎1例报告
- Author:
Dao-Pei LI
1
Author Information
1. 广东省中山市小榄人民医院(中山市第五人民医院),中山 528415
- Keywords:
Balamuthia mandrillaris encephalitis;
gene sequencing;
cerebrospinal fluid;
hypoalbuminemia;
hypokalemia;
hypernatremia
- From:
Chinese Journal of Zoonoses
2024;40(7):696-700
- CountryChina
- Language:Chinese
-
Abstract:
This article reports a case of amoebic encephalitis caused by Balamuthia mandrillaris in a 76-year-old rural fe-male patient,including clinical manifestations,laboratory examinations,and treatment results.This study explored the clinical characteristics,diagnostic methods,and treatment strategies for amoebic encephalitis caused by Balamuthia mandrillaris.A retrospective analysis of the patient's medical records was conducted.At admission,the patient's examination findings were ab-normal,with positive IgM for respiratory pathogens,and 55 detected sequences of Balamuthia mandrillaris according to Huada Gene Sequencing.Cerebrospinal fluid analysis indicated a white blood cell count of 371 × 106/L,protein level of 3 321.4 mg/L,glucose level of 2.33 mmol/L,and chloride level of 110 mmol/L,thereby indicating severe infection and immune disor-ders.After 6 days of treatment,the patient's condition had improved slightly but remained critical.Because of the lack of specif-ic drug treatments,the patient's prognosis was extremely poor,and her family requested discharge.Amoebic encephalitis caused by Balamuthia mandrillaris is a rare but dangerous disease with diverse clinical manifestations,difficult diagnosis,and lack of specific drugs,thus making treatment extremely difficult and leading to poor prognosis.For patients suspected of having amoebic encephalitis caused by Balamuthia mandrillaris,comprehensive treatment should be initiated early and should include anti-infection and immune regulation measures.
