Recent advances and challenges regarding epigenetic modification in HIV infection
10.3969/j.issn.1002-2694.2024.00.075
- VernacularTitle:HIV感染的表观遗传学修饰:研究进展与挑战
- Author:
Ai-Ping CHEN
1
;
Lian-Gui FENG
;
Yong-Jun ZHANG
Author Information
1. 重庆医药高等专科学校,重庆 401331;高致病性病原微生物重庆市重点实验室,重庆 400042
- Keywords:
Human Immunodeficiency Virus;
epigenetics;
DNA methylation;
histone modification;
non-coding RNAs;
RNA modofication
- From:
Chinese Journal of Zoonoses
2024;40(6):556-563
- CountryChina
- Language:Chinese
-
Abstract:
The establishment and maintenance of latent cellular reservoirs of human immunodeficiency virus(HIV)within days after infection remains a major obstacle to achieving functional HIV cure.Epigenetics pertains to the regulation of gene ex-pression through means beyond mutations in DNA sequences.Research on epigenetic modifications in recent decades has facili-tated in-depth understanding of HIV pathogenesis and ongoing AIDS therapy strategies.This review briefly introduces princi-ples of epigenetics,and summarizes current epigenetic findings observed during HIV infection,particularly regarding the roles of epigenetic mechanisms including DNA methylation,histone modification,RNA modification,and non-coding RNAs in the processes of viral latency and formation of reservoirs.In addition,the implications and challenges of these epigenetic regulatory mechanisms in functional AIDS cure strategies are discussed.This review is aimed at encouraging more research groups to focus on epigenetic studies in HIV-infected populations,to develop more therapeutic drugs based on epigenetics,and to propose more rational and feasible functional AIDS cure strategies.
