Clinical efficacy of anterior cruciate ligament reconstruction under knee arthroscopy combined with platelet rich plasma intra-articular injection for the treatment of anterior cruciate ligament injury
- VernacularTitle:膝关节镜下前交叉韧带重建术联合富血小板血浆关节腔注射治疗前交叉韧带损伤的临床疗效研究
- Author:
He HUANG
1
;
Yang WANG
;
Miao DENG
Author Information
- Keywords: arthroscopy; anterior cruciate ligament reconstruction(ACLR); platelet rich plasma(PRP); intra-articular injection; anterior cruciate ligament(ACL)injury; limb function; stress reaction; femoral tunnel diameter
- From: China Journal of Endoscopy 2024;30(10):83-90
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the clinical efficacy of anterior cruciate ligament reconstruction(ACLR)and platelet rich plasma(PRP)intra-articular injection under knee arthroscopy for the treatment of anterior cruciate ligament(ACL)injury.Methods From January 2022 to January 2023,70 patients with ACL injury were randomly divided into control group(35 cases,using ACLR under knee arthroscopy)and study group(35 cases,using ACLR under knee arthroscopy combined with PRP intra-articular injection)using a random number table method.The limb function,femoral tunnel diameter,tendon bone healing,body stress indicators,insulin-like growth factor-1(IGF-1),osteocalcin,and matrix metalloproteinase-1(MMP-1)were compared between the two groups.Results At 4 weeks after operation,the levels of malondialdehyde and nitric oxide(NO)in both groups were lower than those before surgery,and the study group was lower than the control group,the levels of superoxide dismutase(SOD)in both groups were higher than those before surgery,and the study group was higher than the control group,the differences were all statistically significant(P＜0.05).At 24 weeks after operation,Lysholm score and International Knee Documentation Committee(IKDC)score of both groups were higher than those before operation,and the study group was higher than the control group,the differences were all statistically significant(P＜0.05).At 24 weeks after operation,the levels of IGF-1 in both groups were higher than those before operation,and the study group was higher than the control group,the levels of osteocalcin and MMP-1 in both groups were lower than those before operation,and the study group was lower than the control group,the differences were all statistically significant(P＜0.05).At 24 weeks after surgery,the femoral tunnel diameter in both groups was greater than before surgery,however,the study group was smaller than the control group,the differences were all statistically significant(P＜0.05).The overall tendon bone healing in the study group was better than that in the control group,the difference was statistically significant(Z=-2.22,P=0.026).Conclusion ACLR under knee arthroscopy combined with PRP intra-articular injection can improve the limb function of patients with ACL injury,alleviate body stress,prevent the expansion of femoral tunnel diameter,promote tendon bone healing,increase IGF-1 and reduce osteocalcin,and MMP-1.
