Expression of CD14+CD277+monocyte macrophage and PD-1 on T cells predict clinical outcome of respiratory support therapy in children with ARDS
10.3969/j.issn.1000-484X.2024.12.025
- VernacularTitle:CD14+CD277+单核-巨噬细胞、T细胞上PD-1的表达对ARDS患儿呼吸支持治疗临床转归的预测
- Author:
Dongmei ZHANG
1
;
Laishuan WANG
;
Haiyan YING
Author Information
1. 通用医疗三二〇一医院新生儿科,汉中 723000
- Keywords:
Acute respiratory distress syndrome;
CD14+;
CD277+;
Monocyte-macrophage;
Programmed death receptor 1;
Prog-nosis
- From:
Chinese Journal of Immunology
2024;40(12):2609-2613,2622
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of the expression of CD14+CD277+monocyte macrophage and pro-grammed death receptor-1(PD-1)on T cells in clinical outcome of children with acute respiratory distress syndrome(ARDS).Meth-ods:The clinical data of 130 children with ARDS in 3201 hospital from April 2014 to March 2020 were respectively analyzed.After 28 days of treatment,the children were divided into survival group and death group according to their survival status.The levels of PD-1 on CD14+CD277+monocyte macrophages and T cells in survival group and death group were compared.The independent risk factors af-fecting the outcome of the children and the value of PD-1 levels on CD14+CD277+monocyte-macrophages and T cells in predicting the death of the children were analyzed.Results:The proportion of CD14+CD277+monocyte-macrophages and MFI in the death group were higher than those in the survival group(P<0.05).Multivariate Logistic regression analysis showed that gestational age,Apgar score at 5 min after birth,hypoalbuminemia,CD14+CD277+monocyte macrophage and PD-1 on T cells were independent risk factors for death(P<0.05).The area under the ROC curve of CD14+CD277+monocyte macrophage was 0.777(95%CI:0.698～0.855,P=0.000),the cut-off value was 0.105%,the corresponding sensitivity was 81.96%,and the specificity was 55.67%.The area under ROC curve of PD-1 on T cells was 0.756(95%CI:0.674～0.838,P=0.000),and the cutoff value for predicting death was 114 MFI.The sensitivity and specificity were 80.45%and 58.23%.Conclusion:The level of PD-1 on CD14+CD277+monocyte-macrophages and T cells is relat-ed to the prognosis of neonates with ARDS,and its higher level indicates poor prognosis and a higher risk of death.
