Humanized immune system mouse model and its application in tumor immunotherapy
10.3969/j.issn.1000-484X.2024.10.001
- VernacularTitle:免疫系统人源化小鼠及其在肿瘤免疫治疗中的应用
- Author:
Chenkun WANG
1
;
Haofei LIU
Author Information
1. 中国科学院苏州纳米技术与纳米仿生研究所,纳米生物医学部纳米-生物界面重点实验室,类器官创新中心,苏州 215123
- Keywords:
Immunodeficient mice;
Humanized immune system mouse model;
Tumor;
Immunotherapy
- From:
Chinese Journal of Immunology
2024;40(10):2017-2030
- CountryChina
- Language:Chinese
-
Abstract:
Effectiveness of tumor immunotherapy is largely evaluated based on mouse models.Due to species differences,traditional mouse models cannot mirror condition of immune response in human body,resulting in vast majority of mouse-based achievements are not applicable to humans.In recent years,with emergence of immunodeficient mice and its improvement,humanized immune system mouse models based on immunodeficient mice are expected to help us overcome this barrier.We highlight the latest advances and barriers in generation of immunodeficient mice and humanized mouse models,as well as application of humanized mouse models on tumor immune,with aim of providing a guide for their application to tumor immunotherapy studies with potential for clinical translation.
