Progress in research on characteristics of CD4+CD28-T cells and their roles in diseases
10.3969/j.issn.1000-484X.2024.08.033
- VernacularTitle:CD4+CD28-T细胞的特点及其在疾病中的作用研究进展
- Author:
Qian LIN
1
;
Zilong WANG
;
Guan WANG
;
Chang LIU
Author Information
1. 大连理工大学附属中心医院风湿免疫科,大连 116033
- Keywords:
CD4+CD28-T cells;
Inflammatory response;
Cytotoxicity
- From:
Chinese Journal of Immunology
2024;40(8):1779-1784,1788
- CountryChina
- Language:Chinese
-
Abstract:
In healthy young people,the expression of CD28 in regular CD4+T cells is 97.5%.However,studies have shown that in the elderly and patients with chronic inflammation and persistent infection,the positiveness of CD28 in CD4+T cells decrease significantly,even less than 50%,that is,the accumulation of CD4+CD28-T cells.CD4+CD28-T cells are a unique subset of CD4+T cells.In this review,we describes the characteristics of phenotype and function and their roles in chronic viral infections,autoimmune diseases,cardiovascular diseases of CD4+CD28-T cells,providing new strategies for the treatment and prognosis improvement of CD4+CD28-T cell-related diseases.
