Role of exosomal noncoding RNA from adipose-derived mesenchy-mal stem cells in wound healing

VernacularTitle:脂肪间充质干细胞外泌体源非编码RNA在创面愈合中的作用
Author: Lihua LIU ¹ ; Dewu LIU
Author Information

1. 南昌大学第一附属医院烧伤整形与创面修复医学中心,南昌 330006,江西;南昌大学焕奎书院,南昌 330006,江西
Keywords: adipose-derived mesenchymal stem cells; exosomes; noncoding RNA; wound healing
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2024;29(9):1049-1056
CountryChina
Language:Chinese
Abstract: Exosomes(Exos)are nano-sized mem-brane vesicles actively secreted by adipose-derived mesenchymal stem cells(ADSCs),carrying bioactive molecules such as long non-coding RNA(lncRNA),microRNA(miRNA),and circular RNA(circRNA),which are non-coding RNAs(ncRNA)that enter into the corresponding target cells and participate in in-tercellular communication.ADSC-Exo-ncRNA can regulate the immune and inflammatory response,angiogenesis,accelerate skin cell proliferation and epithelialization,and regulate collagen remodeling,thereby enhancing wound repair ability.Therefore,ADSC-Exo-ncRNA exerts an significant role in the process of wound repair and provides a promising strategy for treatment.In this paper,we review the role of ADSC-Exo-ncRNA in wound healing and its application prospects in recent year.