Advances in clinical research of CAR-T immunotherapy for systemic rheumatic diseases
10.12092/j.issn.1009-2501.2024.08.011
- VernacularTitle:系统性风湿性疾病CAR-T免疫疗法临床研究进展
- Author:
Zhi LI
1
;
Mengying ZHANG
;
Chuanmiao ZHU
;
Li MAO
;
Hui PENG
Author Information
1. 皖南医学院第一附属医院风湿免疫科,芜湖 241000,安徽
- Keywords:
CAR-T;
rheumatic disease;
systemic lupus erythematosus;
sjogren syndrome
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(8):937-946
- CountryChina
- Language:Chinese
-
Abstract:
Systemic rheumatic disease is a kind of autoimmune disease which is caused by the dys-function of autoimmune cells and the damage of multiple systems and organs.Traditional immuno-suppressants play an important role in the treat-ment of systemic rheumatic diseases,but there are still a considerable number of refractory systemic rheumatic diseases that do not respond well to tra-ditional immunosuppressant therapy,and new ther-apeutic methods need to be explored.Chimeric an-tigen receptor T cell therapy(CAR-T)immunothera-py was initially used for the treatment of malig-nant hematological diseases and has shown good efficacy.Recently,CAR-T immunotherapy has also achieved remarkable efficacy in refractory systemic lupus erythematosus.It brings new hope for the treatment of systemic rheumatic diseases.This arti-cle summarizes the progress of clinical application of CAR-T immunotherapy in systemic rheumatic dis-eases in recent years,aiming to enhance clinicians'cognition of CAR-T immunotherapy and promote the further development of CAR-T immunotherapy in systemic rheumatic diseases.
