Progress in the treatment of lipid deposition in diabetic nephropathy with traditional Chinese medicine targeting nuclear receptors
10.12092/j.issn.1009-2501.2024.06.010
- VernacularTitle:核受体调控糖尿病肾病脂质积累及中药复方干预的研究进展
- Author:
Wenhui ZHU
1
;
Yao CHEN
;
Yonggang ZHANG
;
Peng LIU
Author Information
1. 黑龙江省中医药科学院医学部肾病科,哈尔滨 150000,黑龙江
- Keywords:
nuclear receptors;
diabetic nephropa-thy;
lipid accumulation;
Chinese herbal medicine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(6):680-689
- CountryChina
- Language:Chinese
-
Abstract:
Dysfunction of nuclear receptors(NRs),which are critical for maintaining renal lipid homeostasis,largely contributes to the progression of diabetic nephropathy(DN)by promoting renal lipid accumulation.However,there are few thera-pies in modern medicine that effectively inhibit re-nal lipid accumulation by modulating NRs.In this review,we first summarize recent advances in NRs-mediated renal lipid accumulation in DN.Then,we summarize recent studies on the effects and mech-anisms of Chinese herbal medicines on DN and highlight the effects of Chinese herbal medicines on renal lipid accumulation via NRs.In addition,the advantages and limitations of traditional Chi-nese medicine in the treatment of DN via NRs-me-diated renal lipid accumulation are analyzed,and the modulation of renal lipid accumulation via NRs is emphasized as a promising therapeutic strategy for the treatment of DN.
