Correlation analysis between coma recovery scale and event-related potential in patients with prolonged disorders of consciousness
10.3969/j.issn.1001-1242.2024.05.008
- VernacularTitle:慢性意识障碍患者昏迷恢复量表与事件相关电位的相关性分析
- Author:
Yi DONG
1
;
Hao TAN
;
Xi TAO
Author Information
1. 湖南师范大学第一附属医院,湖南省人民医院康复医学科,湖南省脑血管病康复临床医学研究中心,湖南省长沙市,410016
- Keywords:
event-related potentials;
mismatch negativity;
chronic disturbance of consicousness;
the coma recovery scale-revised
- From:
Chinese Journal of Rehabilitation Medicine
2024;39(5):663-668
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between coma recovery scale(CRS-R)and event-related potential MMN and P300 in patients with prolonged disorders of consciousness,thereby establishing the clinical value of CRS-R scale combined with event-related potential in assessing the level of consciousness in these patients. Method:Sixty-one patients with disturbance of consciousness were enrolled according to the inclusion criteria,and all patients completed the CRS-R assessment and event-related potential(MMN and P300)within the same time period(72 hours).The data collected were first subjected to a normality test,and the data with normal distribution were examined by pearson correlation analysis,while the data that did not fit a normal dis-tribution were analyzed using spearman correlation.Then,the two sets of data that showed correlation were fur-ther analyzed using multivariate linear regression,considering multiple factors such as age,gender,duration,etiology,BMI,level of consciousness. Result:Considering confounding factors(age,gender,duration of illness,etiology,BMI,and level of conscious-ness),there were correlations between CRS-R(hearing)and MMN(F4 latency);CRS-R(vision)and MMN(Cz amplitude);MMN(Fz amplitude),MMN(F3 amplitude),CRS-R(movement)and MMN(Cz amplitude)and MMN(F4 amplitude);CRS-R(arousal)and MMN(F4 latency);CRS-R(total score)and MMN(Cz am-plitude).The correlation coefficients was significant:Cz(amplitude)with CRS-R(motion)at 0.759,F4(ampli-tude)with CRS-R(motion)at 0.689,Fz(amplitude)with CRS-R(vision)at 0.685.There were also correla-tions between CRS-R(auditory)and P300(F3 amplitude),CRS-R(visual)and P300(Cz amplitude),CRS-R(mouth movement)and P300(F4 latency,Fz latency). Conclusion:There are significant correlations between the various scoring items of CRS-R scale and the ampli-tude and latency of MMN and P300 electrode points.These findings provide objective and direct electrophysio-logical evidence to support the clinical behavioral evaluation of chronic consciousness disorder.
