Research progress on epigenetic regulatory pathways of in-stent restenosis
10.3969/j.issn.1004-8812.2024.11.007
- VernacularTitle:支架内再狭窄表观遗传调控通路研究进展
- Author:
Wen-Chao DOU
1
;
Yu PENG
;
Zheng ZHANG
Author Information
1. 兰州大学第一临床医学院,甘肃兰州 730000
- Keywords:
Percutaneous coronary intervention;
In-stent restenosis;
Epigenetic regulation;
Signaling pathways
- From:
Chinese Journal of Interventional Cardiology
2024;32(11):648-652
- CountryChina
- Language:Chinese
-
Abstract:
Percutaneous coronary intervention(PCI)is the main treatment for coronary heart disease.Despite the continuous development of drug-eluting stent(DES)technology,about 10％of patients still develop in-stent restenosis(ISR)after second-generation DES implantation.ISR is characterized by progressive lumen stenosis within the stent,which is the result of PCI-induced mechanical damage to the arterial wall of the target segment.The pathophysiological mechanism of ISR is not well understood,but it is currently thought that vascular inflammation,platelet activation,vascular smooth muscle cells(VSMCs)proliferation and migration,and extracellular matrix remodeling are responsible for neointimal hyperplasia leading to arterial lumen re-stenosis,resulting in the occurrence and evolution of ISR.Therefore,this review explored the molecular pathological mechanism of ISR under epigenetic regulation after PCI,and found more precise and effective targets to prevent the occurrence and development of ISR in order to inhibit the proliferation and migration of VSMCs without affecting the reendothelialization of vascular intima and endothelialization.
