Research progress on the association between lipoprotein(α)and mitral annulus calcification
10.3969/j.issn.1004-8812.2024.05.005
- VernacularTitle:脂蛋白(α)与二尖瓣环钙化关系的研究进展
- Author:
Bin ZHANG
1
;
Zhi-Qiang PEI
;
Deng-Feng MA
;
Jin QIU
;
Qian REN
;
Shu-Zhen ZHAO
Author Information
1. 山西医科大学第九临床医学院 太原市中心医院心内科,山西太原 030009
- Keywords:
Mitral annulus calcification;
Lipoprotein(α);
Aortic valve calcification
- From:
Chinese Journal of Interventional Cardiology
2024;32(5):261-265
- CountryChina
- Language:Chinese
-
Abstract:
Mitral annular calcification(MAC)is an age-related,chronic,degenerative change in localized fibrous support structures,and current research suggests that it is a process similar to the active onset of atherosclerosis and aortic valve calcification,both of which are accompanied by the deposition of lipoprotein(α)[Lp(α)]and the formation of chronic inflammatory foci.Among them,Lp(α)is the hot spot of research.In recent years,the relationship between Lp(α)and aortic valve calcification has received extensive attention.A large number of studies have demonstrated that elevated Lp(α)and its associated oxidized phospholipids(OxPL)can promote aortic valve calcification and stenosis through multiple calcium-regulated pathways,but the pathophysiological process of MAC is much more complex and unclear,and there has been a preliminary exploration of the relationship between Lp(α)and MAC.To make the current relationship between the two clearer,and thus provide new possibilities for preventing or delaying MAC,the paper will review the three aspects of MAC,Lp(α),and the research progress between the two.
