Application of low-dose ticagrelor after stent-assisted embolization of intracranial aneurysm
- VernacularTitle:低剂量替格瑞洛在颅内动脉瘤支架辅助栓塞术后的应用
- Author:
Yang-Fang XIANG
1
;
Yu LIU
;
Zhi-Ling ZHOU
;
Guang-Sen CHENG
Author Information
- Keywords: intracranial aneurysm; stent-assisted embolization; low-dose ticagrelor
- From: Journal of Regional Anatomy and Operative Surgery 2024;33(12):1073-1076
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the application effect of low-dose ticagrelor combined with aspirin in patients with intracranial aneurysm after stent-assisted embolization.Methods The clinical data of patients with unruptured intracranial aneurysm who underwent stent-assisted embolization in our hospital from January 2021 to January 2023 were retrospectively analyzed and divided into the ticagrelor group[aspirin(100 mg,once a day)+low-dose ticagrelor(60 mg,twice a day)]and the clopidogrel group[aspirin(100 mg,once a day)+clopidogrel(75 mg,once a day)]according to the preoperative dual antiplatelet therapy regimen.A total of 158 patients who underwent stent-assisted embolization were included,including 84 patients in the ticagrelor group and 74 patients in the clopidogrel group.The patients were followed up for 3 months after surgery,and the occurrence of ischemic events and hemorrhagic events in the two groups were observed and compared.Results There was no statistically significant difference in the incidence of hemorrhagic events 3 months after surgery(11.9%vs.12.2%)between the ticagrelor group and the clopidogrel group(P>0.05).There was a statistically significant difference in the incidence of ischemic events 3 months after surgery(11.9%vs.25.7%)between the ticagrelor group and theclopidogrel group(P<0.05).Multivariate Cox regression analysis showed that low-dose ticagrelor(HR=0.44,95%CI:0.21 to 0.93,P=0.035)was a protective factor for ischemic events after stent-assisted embolization.Conclusion Compared with clopidogrel,the application of low-dose ticagrelor(60 mg,twice a day)after stent-assisted embolization of intracranial aneurysm can significantly reduce the incidence of postoperative ischemic stroke events,and low-dose ticagrelor combined with aspirin can be used as a dual antiplatelet therapy regimen after stent-assisted embolization of intracranial aneurysm.
