Research progress of aerobic glycolysis in liver cancer
- VernacularTitle:有氧糖酵解在肝癌中的研究进展
- Author:
Qiang WANG
1
;
Zhi-Qing ZHANG
Author Information
- Keywords: aerobic glycolysis; key enzymes; hepatocellular carcinoma; hexokinase; Warburg effect; pyruvate kinases
- From: Journal of Regional Anatomy and Operative Surgery 2024;33(11):963-966
- CountryChina
- Language:Chinese
- Abstract: Liver cancer has the fifth morbidity and the third mortality among maligant tumors in the worldwide,and hepatocellular carci-noma(HCC)accounts for 90% of primary liver cancer.Aerobic glycolysis,as a hallmark of hepatoma cell energy metabolism,is firstly found in HCC and responsible for the regulation of cell proliferation,immune evasion,invasion,metastasis,and drug resistance.There are three rate-limiting enzymes in the glycolysis,including phosphofructokinase 1(PFK1),pyruvate kinases type M2(PKM2)and hexokinase 2(HK2),which play an important role in the regulation of aerobic glycolysis and can be regulated by many mechanisms.Because of the impor-tance of aerobic glycolysis in the occurrence and development of HCC,targeting and blocking key factors in its pathway may be a potential therapeutic treatment for HCC.With the development of key enzymes activations/inhibitors of aerobic glycolysis,the prospect of targeted therapy should be expected.Therefore,this article reviews the research progress of aerobic glycolysis in liver cancer,and summarize the role of aerobic glycolysis in the development and treatment of liver cancer,in order to provide clinical reference.
