Research progress on ferroptosis and iron homeostasis in regulating idiopathic pulmonary fibrosis under oxidative stress
10.3760/cma.j.cn341190-20240326-00306
- VernacularTitle:氧化应激下铁死亡及铁稳态调节IPF的研究进展
- Author:
Ke ZHAO
1
;
Hong SUO
Author Information
1. 内蒙古医科大学研究生院，呼和浩特 010000
- Keywords:
Idiopathic pulmonary fibrosis;
Oxidative stress;
Cell death;
Iron;
Lipid peroxides;
Review
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(11):1756-1760
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology with a complex pathogenesis. In recent years, ferroptosis, a regulated form of cell death, has been identified as a significant factor in various diseases. Current research indicates that the imbalance in the regulation of ferroptosis and iron homeostasis under oxidative stress is closely related to the onset and progression of IPF. This article reviews the mechanisms by which oxidative stress contributes to the development of IPF, as well as how the dysregulation of ferroptosis and iron homeostasis under oxidative stress leads to the disease. Findings from this article provide new insights and potential therapeutic targets for further investigation of IPF.
