Efficacy and safety of amlodipine besylate and benazepril hydrochloride tablets (Ⅱ) in the treatment of hypertension in older adult patients
10.3760/cma.j.cn341190-20240423-00447
- VernacularTitle:氨氯地平贝那普利片（Ⅱ）治疗老年人高血压的疗效及安全性评价
- Author:
Rui WANG
1
;
Fei HONG
Author Information
1. 辽宁省金秋医院心血管内科，沈阳 110000
- Keywords:
Hypertension;
Drug therapy;
Antihypertensive agents;
Amlodipine;
Blood pressure;
Drug-related side effects and adverse reactions;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(10):1502-1506
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of amlodipine besylate and benazepril hydrochloride tablets (Ⅱ) in the treatment of primary hypertension in older adult patients.Methods:A total of 100 older adult patients with primary hypertension of grade 2 or higher who received outpatient and inpatient treatment at The Jinqiu Hospital of Liaoning Province from July to December 2023 were included in this study. They were treated with amlodipine besylate and benazepril hydrochloride tablets (Ⅱ), 1 tablet per day, for 8 successive weeks. The time to achieve target blood pressure and the time to reach stable drug concentration in the blood were monitored.Results:Among the 100 patients, there were 60 with grade 2 hypertension and 40 with grade 3 hypertension. Of the patients, 53 were male, with an average age of (76.41 ± 6.70) years, and 47 were female, with an average age of (77.34 ± 7.60) years. The overall target achievement rate for patients with grade 2 hypertension after treatment was 95.0% (57/60), which was significantly higher than the 80.0% (32/40) for patients with grade 3 hypertension (χ2 = 4.09, P = 0.043). The average time to achieve target blood pressure for patients with grade 2 hypertension was 7.5 days, with an average effective duration of 4.5 days. The average to achieve target blood pressure for patients with grade 3 hypertension was 13.2 days, with the average effective duration of 6.1 days. The differences in systolic and diastolic blood pressure among the 100 patients at 1, 2, 4, and 8 weeks of treatment were statistically significant (all P < 0.001). The blood pressure achievement rates for patients with grade 2 hypertension at 1, 2, and 4 weeks were significantly higher than those for patients with grade 3 hypertension (all P < 0.05). At 1 week of treatment, the effective rate for patients with grade 2 hypertension was significantly higher than that for patients with grade 3 hypertension (χ2 = 7.16, P = 0.007). There was no statistically significant difference in the incidence of adverse reactions between patients with grade 2 and grade 3 hypertension (χ2 = 0.22, P = 0.640). Conclusion:Amlodipine besylate and benazepril hydrochloride tablets (Ⅱ) are effective in lowering blood pressure in older adults with hypertension. They significantly lower blood pressure while maintaining a low incidence of adverse reactions.
