Human infective endocarditis caused by Bartonella vinsonii subsp.berk-hoffii:one case report and literature review
10.12138/j.issn.1671-9638.20245184
- VernacularTitle:文森巴尔通体致人类感染性心内膜炎1例报告并文献复习
- Author:
Jun-Yan YAN
1
;
Rui-Yan MA
;
Ying-Bin XIAO
;
Jia HAO
;
Ming-Wen LI
;
Jian LI
;
Lin CHEN
;
Ying-Jiu JIANG
Author Information
1. 重庆医科大学附属第一医院,重庆 400042;中国人民解放军陆军军医大学第二附属医院新桥医院,重庆 400037
- Keywords:
infective endocarditis;
Bartonella;
metagenomic next-generation sequencing technology;
negative blood culture
- From:
Chinese Journal of Infection Control
2024;23(10):1295-1301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and treatment strategies of infective endocarditis caused by Bartonella vinsonii subsp.berkhoffii(Bvb).Methods Clinical diagnosis and treatment of a 25-year-old male patient with infective endocarditis caused by Bvb in China was reported,combined with literatures about three similar cases reported abroad were summarized and analyzed.Results All 4 patients were young and middle-aged males with a history of close contact with canines in the past one year.The main symptoms were chest pain,fa-tigue,and dyspnea,accompanied by cerebrovascular accidents and severe anemia,as well as the formation of heart valve vegetations and valve function impairment.Multiple blood cultures were negative,2 and 3 cases were con-firmed to be infected with Bvb through metagenomic next-generation sequencing(mNGS)of pathogenic microorga-nisms and polymerase chain reaction respectively.All patients underwent surgical treatment due to heart failure,and all survived after surgery and targeted anti-infective treatment.Conclusion This case report is the first case of Bvb infective endocarditis in China.Patient's diagnosis is confirmed by serum indirect immunofluorescence assay and mNGS,combination of surgery and anti-infective treatment has achieved ideal effect.
