Rifampicin resistance and its influencing factors in re-treated pulmonary tuberculosis patients in Chongqing City from 2018 to 2022
10.12138/j.issn.1671-9638.20244933
- VernacularTitle:2018-2022年重庆市复治肺结核患者利福平耐药情况及影响因素
- Author:
Rong-Rong LEI
1
;
Jian CHEN
;
Lin SHI
;
Ya YU
Author Information
1. 重庆市结核病防治所区县科,重庆 400050
- Keywords:
re-treatment of pulmonary tuberculosis;
rifampicin resistance;
influencing factor
- From:
Chinese Journal of Infection Control
2024;23(7):847-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the status and influencing factors of rifampicin resistance in re-treated pulmonary tuberculosis(PTB)patients registered in Chongqing City,and provide basis for the prevention and control of drug-resistant tuberculosis in this city.Methods Descriptive epidemiological method was adopted to analyze the status of rifampicin resistance in re-treated PTB patients registered in districts and counties of Chongqing City from 2018 to 2022.Chi-square test and binary logistic regression were used to analyze the influencing factors for the status of ri-fampicin resistance in re-treated PTB patients.Results The detection rate of rifampicin resistance in re-treated PTB patients in districts and counties of Chongqing City from 2018 to 2022 was 14.45％(558/3 862),presenting an overall downward trend(x2trend=22.739,P＜0.001).Univariate analysis showed that among re-treated PTB pa-tients,the detection rate of rifampicin resistance was the highest among migrant population,residents in urban areas,workers,and migrant workers(all P＜0.05);rifampicin resistance decreased with the increase of age(Ptrend＜0.001).Multivariate logistic regression analysis showed that the risk of rifampicin resistance gradually decreased with the increase of age;OR value decreased from 2.778 in the＜25 year old group to 1.654 in the ≥45 year old group(all P＜0.001).The risk factors for rifampicin resistance in re-treated PTB patients were migrant popula-tion,residents in urban areas,workers,and migrant workers,with statistically significant differences(all P＜0.05).Conclusion Although the detection rate of rifampicin resistance in re-treated PTB patients in Chongqing has been decreasing year by year,the situation is still severe,and special attention should be paid to the migrant popula-tion,young population,population in the main urban areas,and migrant workers.
