Pathogenesis and research progress of mucosal barrier injury laboratory-confirmed bloodstream infection in patients with acute leukemia
10.12138/j.issn.1671-9638.20244055
- VernacularTitle:急性白血病患者实验室证实的黏膜屏障损伤所致血流感染发生机制与研究进展
- Author:
Hui-Han ZHAO
1
;
Yu HE
;
Yan-Ping YING
Author Information
1. 广西医科大学第一附属医院血液科,广西 南宁 530021;广西医科大学信息与管理学院,广西 南宁 530021
- Keywords:
leukemia;
bloodstream infection;
intestinal barrier;
bacterial translocation
- From:
Chinese Journal of Infection Control
2024;23(5):646-651
- CountryChina
- Language:Chinese
-
Abstract:
Leukemia has become an important threat to human health,and infection complications are the main obstacle to the clinical leukemia treatment.The intestinal barrier integrity was damaged due to the tumor characte-ristics of leukemia and high-intensity chemotherapy,intestinal bacterial translocation is an important cause for bloodstream infection.Mucosal barrier injury laboratory-confirmed bloodstream infection(MBI-LCBI)is an impor-tant component of bloodstream infection in patients with acute leukemia,but relevant research is very limited.The paper reviews the mucosal barrier injury,bacterial translocation,as well as the definition,diagnosis and prevalence of MBI-LCBI,analyzes the mechanism of intestinal microecology in regulating intestinal mucosal barrier integrity and effect of MBI-LCBI,aiming to provide theoretical basis for prevention,treatment and management of chemo-therapy-induced mucositis and MBI-LCBI.
