Roles of intestinal mucosa,intestinal immunity and microbiota in entero-genic Candida albicans infection
10.12138/j.issn.1671-9638.20243298
- VernacularTitle:肠道黏膜、肠道免疫和微生物群在肠源性白念珠菌感染中的作用
- Author:
Hui-Ting CHEN
1
;
Jia-Sheng LI
;
Zhi-Chang XU
;
Ding-Mei QIN
;
Yi ZHANG
;
Rui-Rui WANG
Author Information
1. 云南省中医药大学中药学院分子药理教研室,云南 昆明 650500;云南省民族特色养生理论与健康产品工程实验室,云南 昆明 650500
- Keywords:
enterogenic Candida albicans infection;
intestinal mucosa;
intestinal immunity;
intestinal microbio-ta;
Candida albicans
- From:
Chinese Journal of Infection Control
2024;23(5):631-637
- CountryChina
- Language:Chinese
-
Abstract:
Enterogenic Candida albicans(C.albicans)infection refers to the translocation of intestinal colonized C.albicans under certain conditions,breaking through the intestinal tract,causing tissue infection or even invasive C.albicans infection.As the first contact point of Candida,the intestinal mucosa is the first line defending coloni-zation or invasion of C.albicans,often inhibiting infection by physical barrier and activating host immunity.As an-other defense mechanism,the intestinal microbiota jointly resists the invasive infection of C.albican through regula-ting pH,secreting antimicrobial peptides,and competing for adhesion points.This review summarizes the roles of three key factors,namely intestinal mucosa,intestinal immunity and microbiota,in enterogenic C.albicans infec-tion,providing new ideas for scientific research on invasive candidiasis caused by intestinal colonization.
