Progress in the glycocalyx and atherosclerosis
10.20039/j.cnki.1007-3949.2024.11.010
- VernacularTitle:糖萼与动脉粥样硬化的研究进展
- Author:
Abuduhelili NUERKEZI
1
;
Hong WU
Author Information
1. 海军军医大学附属长海医院心内科,上海市 200433
- Keywords:
atherosclerosis;
glycocalyx;
acetaparan sulfate;
hyaluronic acid
- From:
Chinese Journal of Arteriosclerosis
2024;32(11):994-998
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is the most common disease in cardiovascular and cerebrovascular diseases,and vascular endothelial dysfunction is the initial stage of atherosclerosis.As a physical barrier between the flowing blood and the en-dothelium,glycocalyx can participate in the occurrence and development of atherosclerosis by regulating vascular permeabili-ty,diastolic function,intercellular communication and inflammatory cell adhesion.Therefore,the maintenance or restora-tion of the integrity of the glycocalyx may be a potential therapeutic target for atherosclerosis.Moreover,the abscission level of glycocalyx can reflect the severity of atherosclerosis.Therefore,the level of glycocalyx degradation products(such as acetheparan sulfate,hyaluronic acid,etc)may be used to evaluate the severity of atherosclerosis in the future.This review summarizes the research progress of glycocalyx in atherogenesis.
