Bidirectional two-sample Mendelian randomization study of insomnia and myocardial infarction

VernacularTitle:双向两样本孟德尔随机化分析失眠与心肌梗死的因果关系
Author: Long YU ¹ ; Yingwei LI
Author Information

1. 天津市津南医院心血管内科,天津市 300350
Keywords: insomnia; myocardial infarction; Mendelian randomization; risk factor
From: Chinese Journal of Arteriosclerosis 2024;32(9):783-789
CountryChina
Language:Chinese
Abstract: Aim To explore the association between insomnia and myocardial infarction(MI)using bidirectional two-sample Mendelian randomization(MR).Methods The summary statistics of MI were obtained from genome-wide association studies(GWAS),and single nucleotide polymorphisms(SNP)associated with insomnia phenotype were select-ed as instrumental variables.Inverse variance weighting(IVW)was used to evaluate the causal relationship between in-somnia and MI.Results MR analysis showed that there was positive relationship between insomnia and MI(IVW:OR=1.015,95％CI 1.004～1.027,P=0.007).There was no horizontal pleiotropy and heterogeneity in instrumental variables.Sensitivity analysis suggested that MR analysis results were stable.Reverse MR analysis showed no causal re-lationship between MI and increased risk of insomnia(IVW:OR=0.725,95％CI 0.466～1.126,P=0.152),and the statistical results were stable after the removal of outliers.Conclusion Insomnia is a risk factor for MI and there was positive relationship between insomnia and MI.However,there was no causal relationship between MI and an increased risk of insomnia.