Changes and significance of oxidized phospholipids and endothelial nitric oxide synthase in the acute stage of Kawasaki disease
10.7499/j.issn.1008-8830.2403056
- VernacularTitle:川崎病急性期氧化磷脂和内皮一氧化氮合酶的变化及意义
- Author:
Liu-Rong ZHU
1
;
Xue-Hua HE
;
Yong-Hua YUAN
;
Hao YUAN
;
Xiao-Hui XIA
Author Information
1. 湖南师范大学附属第一医院儿科,湖南长沙 410005
- Keywords:
Kawasaki disease;
Coronary artery lesion;
Serum oxidized phospholipid;
Endothelial nitric oxide synthase;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(8):829-834
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in the serum levels of oxidized phospholipids(OxPLs)and endothelial nitric oxide synthase(eNOS)and their association with coronary artery disease(CAL)in children in the acute stage of Kawasaki disease(KD),as well as the clinical significance of OxPLs and eNOS.Methods A prospective study was conducted on 95 children in the acute stage of KD(KD group).According to the presence of absence of CAL,the KD group was further divided into a CAL subgroup and a non-CAL(NCAL)subgroup.Thirty children with fever due to lower respiratory tract infection were enrolled as the fever group.Thirty healthy children who underwent physical examination were enrolled as the healthy control group.The above groups were compared in terms of general information and serum levels of OxPLs,eNOS and other laboratory indexes,and the correlation between OxPLs level and eNOS level was analyzed.Results The KD group had a significantly higher level of OxPLs and a significantly lower level of eNOS compared with the fever group and the healthy control group(P<0.05).After treatment,the children with KD had a significantly decreased OxPLs level and a significantly increased eNOS level(P<0.05).Compared with the NCAL subgroup,the CAL subgroup had a significantly higher level of OxPLs and a significantly lower level of eNOS(P<0.05).Among the children of KD,the level of OxPLs was negatively correlated with that of eNOS(rs=-0.353,P<0.05).Conclusions Serum OxPLs and eNOS in the acute stage of KD may be involved in the development of CAL in children with KD,and therefore,they may be used as the biomarkers to predict CAL in these children.
