Advances in Mendelian randomization studies on autism spectrum disorder
10.7499/j.issn.1008-8830.2311030
- VernacularTitle:孟德尔随机化研究在孤独症谱系障碍中的研究进展
- Author:
Yun-Yang HU
1
;
Geng-Chang TIAN
;
Meng LIU
;
Hong WANG
Author Information
1. 武汉科技大学医学部医学院,湖北武汉 430081;华中科技大学同济医学院附属湖北妇幼保健院儿童保健科,湖北武汉 430070
- Keywords:
Autism spectrum disorder;
Mendelian randomization;
Research advance;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(5):535-540
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorder(ASD)is a pervasive neurodevelopmental disorder with onset in infancy or early childhood.Mendelian randomization(MR)is a statistical method used to infer causal relationships between exposures and outcomes.This article summarizes MR studies related to ASD.Existing research supports a causal relationship between maternal inflammatory bowel disease in children with ASD,parental education levels,screen time exposure,obesity,insomnia,serum transferrin,decreased blood selenium,abnormal signals in brain functional MRI,interleukin-6,phosphodiesterase 2A,mitogen-activated protein kinase kinase 3,mitochondrial ribosomal protein L33,serotonin,and ASD.However,it does not support a causal relationship between parental rheumatoid arthritis,systemic lupus erythematosus,neonatal jaundice in children with ASD,cytomegalovirus infection,asthma,oral ulcers,vitamin D levels,and ASD.This article reviews the etiological factors related to ASD and MR studies,aiming to explore and deepen the understanding of the pathophysiology of ASD.It provides strong statistical support for the prevention,diagnosis,and treatment of ASD,and offers new methods and strategies for the etiological analysis of complex traits.
