Safety considerations for the clinical application of recombinant human growth hormone
10.7499/j.issn.1008-8830.2310001
- VernacularTitle:重组人生长激素临床应用的安全性思考
- Author:
Hui PAN
1
;
Hong-Wei DU
Author Information
1. 北京协和医院内分泌科,北京 100032
- Keywords:
Recombinant human growth hormone;
Clinical safety;
Adverse event;
Risk control
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(5):444-449
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant human growth hormone(rhGH)is an effective therapeutic drug for improving short stature.Currently,rhGH can be used for various causes of short stature,including growth hormone deficiency,and the expansion of its clinical application has raised concerns about its safety.Based on existing evidence,when rhGH is used in a standardized manner for physiological replacement therapy,its safety profile is favorable.In clinical practice,attention should be focused on short-term safety during rhGH treatment,with the combination of literature evidence and clinical experience.There is still no definitive conclusion on the long-term safety due to insufficient duration of rhGH treatment.This paper reviews the possible adverse events that may occur during rhGH treatment and their risk control measures,aiming to help clinical physicians understand the overall safety of rhGH treatment and improve its clinical standardization.
