Progress in copper metabolic homeostasis and cuproptosis in cardiovas-cular diseases
10.3969/j.issn.1000-4718.2024.09.021
- VernacularTitle:铜代谢平衡和铜死亡在心血管疾病中的研究进展
- Author:
Pingping HE
1
;
Yan WANG
;
Bei SHI
Author Information
1. 遵义医科大学附属医院心血管内科,贵州 遵义 563000
- Keywords:
copper metabolic homeostasis;
cuproptosis;
cardiovascular diseases
- From:
Chinese Journal of Pathophysiology
2024;40(9):1744-1750
- CountryChina
- Language:Chinese
-
Abstract:
As an essential trace element,copper has major effects on cell metabolism.Therefore,interfering with the balance of copper metabolism in such a way that leads to copper deficiency or excess causes disease.It has been reported that copper metabolic imbalance,or cuproptosis,affects the development of cardiovascular diseases by mediating cellular oxidative stress and vascular remodeling and by interfering with mitochondrial functions.Importantly,copper che-lators,copper ion carriers,small molecule inhibitors of copper chaperones,and dietary copper can alleviate cardiovascu-lar diseases caused by copper metabolic imbalance or cuproptosis.In this review,we comprehensively considered the mo-lecular mechanisms of copper metabolic homeostasis and cuproptosis,as well as their significance and therapeutic advances in cardiovascular diseases,aiming to provide insights on therapeutically targeting copper metabolic homeostasis and cupro-ptosis as a novel strategy for managing cardiovascular diseases.
