Application of multimodal magnetic resonance imaging in the research on depression in Parkinson disease
10.19845/j.cnki.zfysjjbzz.2024.0189
- VernacularTitle:多模态磁共振成像在帕金森病伴抑郁研究中的应用
- Author:
Hui WANG
1
;
Xianjun MA
;
Jianxia XU
Author Information
1. 南京中医药大学附属连云港医院脑病科,江苏 连云港 222004
- Keywords:
Multimodal magnetic resonance imaging;
Parkinson disease;
Depression;
Biomarkers
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(11):993-998
- CountryChina
- Language:Chinese
-
Abstract:
Depression is one of the most common and earliest non-motor symptoms of Parkinson disease(PD)and can significantly increase the burden on PD patients,caregivers,and society.Due to the neglect of non-motor symptoms in clinical diagnosis and treatment and the overlaps between depression and other symptoms of PD,there are serious defi-ciencies in the diagnosis or treatment of depression in PD,and therefore,it is of great significance to identify objective bio-markers for depression in PD and investigate their application value.The development of multimodal magnetic resonance imaging makes it possible to achieve this goal.Multimodal MRI has revealed a wide range of brain lesions in PD with de-pression,with similar pathological changes as primary depression,as well as specific abnormalities in brain structure and function.At present,there is still no exact pathological model for PD with depression,and multimodal MRI has promising application prospects in exploring the pathophysiological mechanisms of PD with depression and identifying the biomarkers for early diagnosis and monitoring.
