Research progress on ubiquitin-proteasome system and nervous system diseases

VernacularTitle:泛素-蛋白酶体系统与神经系统疾病的研究进展
Author: Ruitian TANG ¹ ; Wenhu LIU ; Jin LIANG
Author Information

1. 甘肃省人民医院脑血管病中心,甘肃省脑血管病重点实验室,甘肃兰州 730000
Keywords: Ubiquitin-proteasome system; Degradation; Nervous system; Ubiquitin
From: Journal of Apoplexy and Nervous Diseases 2024;41(6):567-571
CountryChina
Language:Chinese
Abstract: The ubiquitin-proteasome system(UPS)is an internal protein breakdown mechanism regulating a series of cellular life processes.It plays a critical role in protein turnover in most cells to remove old,damaged,and misfolded proteins,which is closely related to the development and progression of various diseases.In recent years,this system has been in the spotlight in various research fields.Studies have shown that abnormal changes in UPS are related to inflamma-tion,diabetes,liver and kidney diseases,and tumors,as well as nervous system diseases.This article reviews the compo-sition of UPS,its role in neurological diseases,and associated therapeutic progress.