Vitamin E ameliorates aflatoxin-induced biochemical changes in the testis of mice
- Author:
R.J.Verma
1
;
Nair ANITA
Author Information
1. Gujarat University
- Keywords:
aflatoxin;
vitamin E;
testis;
biochemical changes
- From:
Asian Journal of Andrology
2001;3(4):305-309
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To assess the effect of aflatoxin on biochemical changes in the testis of mice and the possibility of amelioration by vitamin E treatment. Methods: Adult male albino mice were orally administered with 25 or 50 tg of aflatoxin/animal/day (750 or 1500 μg/kg body weight) for 45 days. The testis was isolated and processed for biochemical analysis. Results: There was a significant, dose-dependent reduction in DNA, RNA, protein, sialic acid contents and the activities of succinic dehydrogenase, adenosine triphosphatase and alkaline phosphatase in the testis of aflatoxintreated mice as compared to the vehicle control. However, the acid phosphatase activity was significantly increased in the aflatoxin-treated mice. Vitamin E (2 mg/animal/day) treatment significantly ameliorated the aflatoxin-induced changes, except the acid and alkaline phosphatase activities in the high dose group. Conclusion: Vitamin E treatment ameliorates the aflatoxin-induced changes in the testis of mice.
